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- Title:
Influence of high pressure on the dimerization of ToxR, a protein involved in bacterial signal transduction.
- Document type:
- Zeitschriftenaufsatz
- Author(s):
- Linke, K., Periasamy, N., Ehrmann, M., Winter, R. and Vogel, R. F.
- Abstract:
- High hydrostatic pressure (HHP) is suggested to influence the structure and function of membranes and/or integrated proteins. We demonstrate for the first time HHP-induced dimer dissociation of membrane proteins in vivo with Vibrio cholerae ToxR variants in Escherichia coli reporter strains carrying ctx:lacZ fusions. Dimerization ceased at 20 to 50 MPa depending on the nature of the transmembrane segments rather than on changes in the ToxR lipid bilayer environment.
- Keywords:
- toxR
- Journal title:
- Appl.Environ. Microbiol
- Year:
- 2008
- Journal volume:
- 74
- Journal issue:
- 24
- Pages contribution:
- 7821-3
- Language:
- en
- Format:
- Text
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