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Titel:

Identification of Salicylates in Willow Bark (Salix Cortex) for Targeting Peripheral Inflammation

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Antoniadou, Kyriaki; Herz, Corinna; Le, Nguyen Phan Khoi; Mittermeier-Kleßinger, Verena Karolin; Förster, Nadja; Zander, Matthias; Ulrichs, Christian; Mewis, Inga; Hofmann, Thomas; Dawid, Corinna; Lamy, Evelyn
Abstract:
Salix cortex-containing medicine is used against pain conditions, fever, headaches, and inflammation, which are partly mediated via arachidonic acid-derived prostaglandins (PGs). We used an activity-guided fractionation strategy, followed by structure elucidation experiments using LC-MS/MS, CD-spectroscopy, and 1D/2D NMR techniques, to identify the compounds relevant for the inhibition of PGE2 release from activated human peripheral blood mononuclear cells. Subsequent compound purification by me...     »
Zeitschriftentitel:
International Journal of Molecular Sciences
Jahr:
2021
Band / Volume:
22
Jahr / Monat:
2021-10
Heft / Issue:
20
Volltext / DOI:
doi:10.3390/ijms222011138
WWW:
https://www.mdpi.com/1422-0067/22/20/11138
Print-ISSN:
1422-0067
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