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Title:

The dynamic range of the human metabolome revealed by challenges

Document type:
Zeitschriftenaufsatz
Author(s):
Krug, Susanne; Kastenmüller, Gabi; Stückler, Ferdinand; Rist, Manuela J.; Skurk, Thomas; Sailer, Manuela; Raffler, Johannes; Römisch-Margl, Werner; Adamski, Jerzy; Prehn, Cornelia; Frank, Thomas; Engel, Karl-Heinz; Hofmann, Thomas; Luy, Burkhard; Zimmermann, Ralf; Moritz, Franco; Schmitt-Kopplin, Philippe; Krumsiek, Jan; Kremer, Werner; Huber, Fritz; Oeh, Uwe; Theis, Fabian J.; Szymczak, Wilfried; Hauner, Hans; Suhre, Karsten; Daniel, Hannelore
Abstract:
Metabolic challenge protocols, such as the oral glucose tolerance test, can uncover early alterations in metabolism preceding chronic diseases. Nevertheless, most metabolomics data accessible today reflect the fasting state. To analyze the dynamics of the human metabolome in response to environmental stimuli, we submitted 15 young healthy male volunteers to a highly controlled 4 d challenge protocol, including 36 h fasting, oral glucose and lipid tests, liquid test meals, physical exercise, and...     »
Journal title:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Year:
2012
Journal volume:
26
Journal issue:
6
Pages contribution:
2607--2619
Fulltext / DOI:
doi:10.1096/fj.11-198093
Print-ISSN:
0892-6638
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