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Title:

Activity-guided discovery of (S)-malic acid 1'-O-beta-gentiobioside as an angiotensin I-converting enzyme inhibitor in lettuce (Lactuca sativa)

Document type:
Zeitschriftenaufsatz
Author(s):
Lagemann, Annika; Dunkel, Andreas; Hofmann, Thomas
Abstract:
Angiotensin-converting enzyme (ACE), playing a crucial role in the renin angiotensin aldosterone system, is well-known to catalyze the conversion of the decapeptide angiotensin I into the physiologically active octapeptide angiotensin II, triggering blood pressure increasing mechanisms. To meet the demand for natural phytochemicals as antihypertensive agents in functional food development, extracts prepared from a series of vegetables were screened for their ACE-inhibitory activity by means of a...     »
Journal title:
Journal of Agricultural and Food Chemistry
Year:
2012
Journal volume:
60
Journal issue:
29
Pages contribution:
7211--7217
Fulltext / DOI:
doi:10.1021/jf3022157
Print-ISSN:
0021-8561
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