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Title:

Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo

Document type:
Zeitschriftenaufsatz
Author(s):
Volz, Nadine; Boettler, Ute; Winkler, Swantje; Teller, Nicole; Schwarz, Christoph; Bakuradze, Tamara; Eisenbrand, Gerhard; Haupt, Larissa; Griffiths, Lyn R.; Stiebitz, Herbert; Bytof, Gerhard; Lantz, Ingo; Lang, Roman; Hofmann, Thomas; Somoza, Veronika; Marko, Doris
Abstract:
This study investigated Nrf2-activating properties of a coffee blend combining raw coffee bean constituents with 5-O-caffeoylquinic acid (CGA) as a lead component with typical roasting products such as N-methylpyridinium (NMP). In cell culture (HT29) the respective coffee extract (CN-CE) increased nuclear Nrf2 translocation and enhanced the transcription of ARE-dependent genes as exemplified for NAD(P)H:quinone oxidoreductase and glutathione-S-transferase (GST)A1, reflected in the protein level...     »
Journal title:
Journal of Agricultural and Food Chemistry
Year:
2012
Journal volume:
60
Journal issue:
38
Pages contribution:
9631--9641
Fulltext / DOI:
doi:10.1021/jf302258u
Print-ISSN:
0021-8561
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