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Title:

ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone

Document type:
Zeitschriftenaufsatz
Author(s):
Behrens, Maik; Frank, Oliver; Rawel, Harshadrai; Ahuja, Gaurav; Potting, Christoph; Hofmann, Thomas; Meyerhof, Wolfgang; Korsching, Sigrun
Abstract:
The teleost v1r-related ora genes are a small, highly conserved olfactory receptor gene family of only six genes, whose direct orthologues can be identified in lineages as far as that of cartilaginous fish. However, no ligands for fish olfactory receptor class A related genes (ORA) had been uncovered so far. Here we have deorphanized the ORA1 receptor using heterologous expression and calcium imaging. We report that zebrafish ORA1 recognizes with high specificity and sensitivity 4-hydroxyphenyla...     »
Journal title:
The Journal of Biological Chemistry
Year:
2014
Journal volume:
289
Journal issue:
28
Pages contribution:
19778--19788
Fulltext / DOI:
doi:10.1074/jbc.M114.573162
Print-ISSN:
0021-9258
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