Benutzer: Gast  Login
Titel:

Activity-guided identification of a chemopreventive compound in coffee beverage using in vitro and in vivo techniques

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Somoza, Veronika; Lindenmeier, Michael; Wenzel, Elisabeth; Frank, Oliver; Erbersdobler, Helmut F.; Hofmann, Thomas
Abstract:
The aim of the present study was to apply an activity-guided screening procedure to coffee brew to identify a key chemopreventive compound by means of in vitro antioxidant tests as well as cell culture experiments and to prove the in vivo activity of that compound by an animal feeding experiment. Solvent fractionation, followed by multiple-step ultrafiltration, revealed that the polar coffee compounds with molecular weights below 1 kDa show the major inhibitory effect on the in vitro peroxidatio...     »
Zeitschriftentitel:
Journal of Agricultural and Food Chemistry
Jahr:
2003
Band / Volume:
51
Heft / Issue:
23
Seitenangaben Beitrag:
6861--6869
Volltext / DOI:
doi:10.1021/jf034750e
Print-ISSN:
0021-8561
 BibTeX