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Titel:

Bitter taste receptors for saccharin and acesulfame K

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Kuhn, Christina; Bufe, Bernd; Winnig, Marcel; Hofmann, Thomas; Frank, Oliver; Behrens, Maik; Lewtschenko, Tatjana; Slack, Jay P.; Ward, Cynthia D.; Meyerhof, Wolfgang
Abstract:
Weight-conscious subjects and diabetics use the sulfonyl amide sweeteners saccharin and acesulfame K to reduce their calorie and sugar intake. However, the intrinsic bitter aftertaste, which is caused by unknown mechanisms, limits the use of these sweeteners. Here, we show by functional expression experiments in human embryonic kidney cells that saccharin and acesulfame K activate two members of the human TAS2R family (hTAS2R43 and hTAS2R44) at concentrations known to stimulate bitter taste. The...     »
Zeitschriftentitel:
The Journal of Neuroscience : the official journal of the Society for Neuroscience
Jahr:
2004
Band / Volume:
24
Heft / Issue:
45
Seitenangaben Beitrag:
10260--10265
Volltext / DOI:
doi:10.1523/JNEUROSCI.1225-04.2004
Print-ISSN:
0270-6474
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