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Titel:

Dietary bread crust advanced glycation end products bind to the receptor for AGEs in HEK-293 kidney cells but are rapidly excreted after oral administration to healthy and subtotally nephrectomized rats

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Somoza, Veronika; Lindenmeier, Michael; Hofmann, Thomas; Frank, Oliver; Erbersdobler, Helmut F.; Baynes, John W.; Thorpe, Suzanne R.; Heidland, August; Zill, Holger; Bek, Stephan; Huber, Jochen; Weigle, Thomas; Scheidler, Sabine; Busch, Andreas E.; Sebeková, Katarína
Abstract:
In renal HEK-293 cells, the dietary Maillard reaction compounds casein-linked Nepsilon-carboxymethyllysine (CML), CML, bread crust (BC), and pronyl-glycine (a key compound formed in association with the process-induced heat impact applied to bread dough) all showed activation of p38-MAP kinase. Expression of the C-terminus truncated receptor for advanced glycation end products (RAGE) resulted in a reduction of HEK-293-MAP kinase activation. As these findings suggested a RAGE-mediated activating...     »
Zeitschriftentitel:
Annals of the New York Academy of Sciences
Jahr:
2005
Band / Volume:
1043
Seitenangaben Beitrag:
492--500
Volltext / DOI:
doi:10.1196/annals.1333.056
Print-ISSN:
0077-8923
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