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Title:

The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK

Document type:
Zeitschriftenaufsatz
Author(s):
Beltran, Leopoldo R.; Dawid, Corinna; Beltrán, Madeline; Gisselmann, Guenter; Degenhardt, Katharina; Mathie, Klaus; Hofmann, Thomas; Hatt, Hanns
Abstract:
For a long time, the focus of trigeminal chemoperception has rested almost exclusively on TRP channels. However, two-pore domain (K2P) potassium channels have recently been identified as targets for substances associated with typical trigeminal sensations, such as numbing and tingling. In addition, they have been shown to be modulated by several TRP agonists. We investigated whether the pungent substances piperine, capsaicin, 6-gingerol and polygodial have an effect on human K2P channels. For th...     »
Journal title:
Frontiers in Pharmacology
Year:
2013
Journal volume:
4
Pages contribution:
141
Fulltext / DOI:
doi:10.3389/fphar.2013.00141
Print-ISSN:
1663-9812
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