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Titel:

Amino acids and peptides activate at least five members of the human bitter taste receptor family

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Kohl, Susann; Behrens, Maik; Dunkel, Andreas; Hofmann, Thomas; Meyerhof, Wolfgang
Abstract:
Amino acids and peptides represent important flavor molecules eliciting various taste sensations. Here, we present a comprehensive assessment of the interaction of various peptides and all proteinogenic amino acids with the 25 human TAS2Rs expressed in cell lines. L-Phenylalanine and L-tryptophan activate TAS2R1 and TAS2R4, respectively, whereas TAS2R4 and TAS2R39 responded to D-tryptophan. Structure-function analysis uncovered the basis for the lack of stereoselectivity of TAS2R4. The same thre...     »
Zeitschriftentitel:
Journal of Agricultural and Food Chemistry
Jahr:
2013
Band / Volume:
61
Heft / Issue:
1
Seitenangaben Beitrag:
53--60
Volltext / DOI:
doi:10.1021/jf303146h
Print-ISSN:
0021-8561
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