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Title:

Joint Base-Calling of Two DNA Sequences With Factor Graphs

Document type:
Zeitschriftenaufsatz
Author(s):
Xiaomeng Shi; Lun, D.S.; Medard, M.; Koetter, R.; Meldrim, J.C.; Barry, A.J.
Abstract:
Automated estimation of DNA base-sequences is an important step in genomics and in many other emerging fields in biological and medical sciences. Current automated sequencers process single strands only. To improve the utility of existing technologies, we propose to mix two independent strands prior to electrophoresis, and base-call jointly by applying the sum-product algorithm on factor graphs. We first present a statistical model for DNA sequencing data and examine the model parameters. A prac...     »
Journal title:
IEEE Transactions on Information Theory
Year:
2010
Journal volume:
Vol. 56
Year / month:
2010-02
Quarter:
1. Quartal
Month:
Feb
Journal issue:
2
Pages contribution:
724-733
Language:
en
WWW:
http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=5420276&tag=1
TUM Institution:
Lehrstuhl für Nachrichtentechnik
Format:
Text
Last change:
30.06.2010
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