First structure-activity relationship of 17&beta;-hydroxysteroid dehydrogenase type 14 nonsteroidal inhibitors and crystal structures in complex with the enzyme.

Title:: First structure-activity relationship of 17β -hydroxysteroid dehydrogenase type 14 nonsteroidal inhibitors and crystal structures in complex with the enzyme.
Author(s):: Braun, F. ; Bertoletti, N. ; Möller, G. ; Adamski, J. ; Steinmetzer, T. ; Salah, M. ; Abdelsamie, A.S. ; Van Koppen, C.J. ; Heine, A. ; Klebe, G. ; Marchais-Oberwinkler, S.
Keywords:: Genetics and Epidemiology
Journal title:: J. Med. Chem.
Year:: 2016
Journal volume:: 59
Pages contribution:: 10719-10737
Fulltext / DOI:: doi:10.1021/acs.jmedchem.6b01436
E-ISSN:: 0022-2623
Impact Factor:: 5,589
Notes:: Research Programmes: Genes and Environment in Common Diseases
TUM Institution:: Institute of Experimental Genetics (IEG)
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First structure-activity relationship of 17&beta; -hydroxysteroid dehydrogenase type 14 nonsteroidal inhibitors and crystal structures in complex with the enzyme.