ChemSICal-Net: Timing-Controlled Chemical Reaction Network for Successive Interference Cancellation in Molecular Multiple Access

Molecular communication (MC) networks between nanoscale biological entities require biologically plausible implementations of signal processing algorithms. Chemical reaction networks (CRNs) provide a natural framework to model such computing processes and capture stochastic effects in simulations. In this work, we present ChemSICal-Net, a stochastic CRN receiver model that implements successive interference cancellation (SIC) for molecular multiple access. The receiver maps SIC to modular chemical building blocks and uses a chemical oscillator for timing control. We further propose an adaptive Bayesian optimization (BO) scheme for tuning reaction rate constants and initial molecule counts, and compare it with baseline optimizers under a fair simulation-cost metric. Then, we evaluate ChemSICal-Net stochastically across clock speeds and configurations using communication metrics such as detection accuracy and decision time. The results show that chemical timing reduces error probability by up to a factor of 2 for short decision times, revealing a direct decision-time/error trade-off. BO reduces the error probability by approximately one order of magnitude compared with non-optimized parameters. Overall, the results support a multi-scale design methodology that combines external optimization with stochastic reaction-level simulation for communication-oriented, timing-controlled CRN receivers in self-organizing living systems.     «

Molecular communication (MC) networks between nanoscale biological entities require biologically plausible implementations of signal processing algorithms. Chemical reaction networks (CRNs) provide a natural framework to model such computing processes and capture stochastic effects in simulations. In this work, we present ChemSICal-Net, a stochastic CRN receiver model that implements successive interference cancellation (SIC) for molecular multiple access. The receiver maps SIC to modular chemic...     »