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Titel:

Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Médard, Guillaume; Pachl, Fiona; Ruprecht, Benjamin; Klaeger, Susan; Heinzlmeir, Stephanie; Helm, Dominic; Qiao, Huichao; Ku, Xin; Wilhelm, Mathias; Kuehne, Thomas; Wu, Zhixiang; Dittmann, Antje; Hopf, Carsten; Kramer, Karl; Kuster, Bernhard
Abstract:
Solid supported probes have proven to be an efficient tool for chemical proteomics. The kinobeads technology features kinase inhibitors covalently attached to Sepharose for affinity enrichment of kinomes from cell or tissue lysates. This technology, combined with quantitative mass spectrometry, is of particular interest for the profiling of kinase inhibitors. It often leads to the identification of new targets for medicinal chemistry campaigns where it allows a two-in-one binding and selectivity...     »
Zeitschriftentitel:
Journal of Proteome Research
Jahr:
2015
Band / Volume:
14
Heft / Issue:
3
Seitenangaben Beitrag:
1574-1586
Volltext / DOI:
doi:10.1021/pr5012608
Verlag / Institution:
American Chemical Society (ACS)
E-ISSN:
1535-38931535-3907
Publikationsdatum:
20.02.2015
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