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Title:

Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors

Document type:
Zeitschriftenaufsatz
Author(s):
Erhart, Friedrich; Hackl, Matthias; Hahne, Hannes; Buchroithner, Johanna; Meng, Chen; Klingenbrunner, Simone; Reitermaier, René; Fischhuber, Katrin; Skalicky, Susanna; Berger, Walter; Spiegl-Kreinecker, Sabine; Lötsch, Daniela; Ricken, Gerda; Kuster, Bernhard; Wöhrer, Adelheid; Widhalm, Georg; Hainfellner, Johannes; Felzmann, Thomas; Dohnal, Alexander M.; Marosi, Christine; Visus, Carmen
Abstract:
Glioblastoma is the most prevalent and aggressive brain cancer. With a median overall survival of ~15–20 months under standard therapy, novel treatment approaches are desperately needed. A recent phase II clinical trial with a personalized immunotherapy based on tumor lysate-charged dendritic cell (DC) vaccination, however, failed to prolong survival. Here, we investigated tumor tissue from trial patients to explore glioblastoma survival-related factors. We followed an innovative approach of com...     »
Keywords:
Cancer therapy; Cell vaccines; CNS cancer; Translational research; Tumour immunology
Journal title:
npj Vaccines
Year:
2020
Journal volume:
5
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41541-019-0149-x
Publisher:
Springer Science and Business Media LLC
E-ISSN:
2059-0105
Date of publication:
16.01.2020
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