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Titel:

Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Erhart, Friedrich; Hackl, Matthias; Hahne, Hannes; Buchroithner, Johanna; Meng, Chen; Klingenbrunner, Simone; Reitermaier, René; Fischhuber, Katrin; Skalicky, Susanna; Berger, Walter; Spiegl-Kreinecker, Sabine; Lötsch, Daniela; Ricken, Gerda; Kuster, Bernhard; Wöhrer, Adelheid; Widhalm, Georg; Hainfellner, Johannes; Felzmann, Thomas; Dohnal, Alexander M.; Marosi, Christine; Visus, Carmen
Abstract:
Glioblastoma is the most prevalent and aggressive brain cancer. With a median overall survival of ~15–20 months under standard therapy, novel treatment approaches are desperately needed. A recent phase II clinical trial with a personalized immunotherapy based on tumor lysate-charged dendritic cell (DC) vaccination, however, failed to prolong survival. Here, we investigated tumor tissue from trial patients to explore glioblastoma survival-related factors. We followed an innovative approach of com...     »
Stichworte:
Cancer therapy; Cell vaccines; CNS cancer; Translational research; Tumour immunology
Zeitschriftentitel:
npj Vaccines
Jahr:
2020
Band / Volume:
5
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41541-019-0149-x
Verlag / Institution:
Springer Science and Business Media LLC
E-ISSN:
2059-0105
Publikationsdatum:
16.01.2020
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