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Title:

Understanding the fouling mitigation mechanisms of alternating crossflow during cell-protein fractionation by microfiltration

Document type:
Zeitschriftenaufsatz
Author(s):
Weinberger, Maria E.; Kulozik, Ulrich
Abstract:
Alternating crossflow filtration is an emerging technology to mitigate fouling in crossflow microfiltration of cell-protein mixtures by periodically reversing the direction of flow. So far, it is understood that the anti-fouling effects are mostly related to the pressure fluctuations upon changing from forward to reversed flow direction and to a smaller extent to the flow reversal along the membrane as such. However, it is not yet clear how pressure fluctuations and flow reversal influence the a...     »
Keywords:
Alternating tangential flow filtration (ATF); Cell retention; Flow reversal; Fouling reversibility; Hydrodynamics; Length dependent fouling
Journal title:
Food and Bioproducts Processing
Year:
2022
Journal volume:
131
Pages contribution:
136--143
Fulltext / DOI:
doi:10.1016/j.fbp.2021.11.003
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