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Title:

Measuring large lipid droplet sizes by probing restricted lipid diffusion effects with diffusion-weighted MRS at 3T

Document type:
Zeitschriftenaufsatz
Author(s):
Weidlich, Dominik; Honecker, Julius; Gmach, Oliver; Wu, Mingming; Burgkart, Rainer; Ruschke, Stefan; Franz, Daniela; Menze, Bjoern H.; Skurk, Thomas; Hauner, Hans; Kulozik, Ulrich; Karampinos, Dimitrios C.
Abstract:
PURPOSE The in vivo probing of restricted diffusion effects in large lipid droplets on a clinical MR scanner remains a major challenge due to the need for high b-values and long diffusion times. This work proposes a methodology to probe mean lipid droplet sizes using diffusion-weighted MRS (DW-MRS) at 3T. METHODS An analytical expression for restricted diffusion was used. Simulations were performed to evaluate the noise performance and the influence of particle size distribution. To val...     »
Journal title:
Magnetic resonance in medicine
Year:
2019
Fulltext / DOI:
doi:10.1002/mrm.27651
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