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Document type:
Buchbeitrag 
Author(s):
Reinecke, Maria; Heinzlmeir, Stephanie; Wilhelm, Mathias; Médard, Guillaume; Klaeger, Susan; Kuster, Bernhard 
Title:
Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery 
Pages contribution:
97-130 
Chapter contribution:
Abstract:
Summary Protein kinases are key regulators of cellular signal transduction with crucial roles for healthy cell biology and pathogenesis. Accordingly many drugs have been developed to address the dysregulation of these enzymes, notably in oncology. Around 50 small molecule kinase inhibitors have already been approved, and hundreds of such drugs are the object of clinical investigation to combat these disease drivers with targeted therapeutic approaches. Due to the conserved structure of the kinas...    »
 
Keywords:
kinase inhibitors, chemical proteomics, Kinobeads, selectivity, mass spectrometry, binding assay 
Book title:
Target Discovery and Validation 
Publisher:
John Wiley & Sons, Ltd 
Year:
2019 
Print-ISBN:
9783527818242