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Document type:
Zeitschriftenaufsatz 
Author(s):
Zecha, Jana; Meng, Chen; Zolg, Daniel Paul; Samaras, Patroklos; Wilhelm, Mathias; Kuster, Bernhard 
Title:
Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics 
Abstract:
The coordination of protein synthesis and degradation regulating protein abundance is a fundamental process in cellular homeostasis. Today, mass spectrometry-based technologies allow determination of endogenous protein turnover on a proteome-wide scale. However, standard dynamic SILAC (Stable Isotope Labeling in Cell Culture) approaches can suffer from missing data across pulse time-points limiting the accuracy of such analysis. This issue is of particular relevance when studying protein stabili...    »
 
Journal title:
Molecular & Cellular Proteomics 
Year:
2018 
Journal volume:
17 
Journal issue:
Pages contribution:
974-992 
Publisher:
Elsevier BV 
E-ISSN:
1535-9476 
Date of publication:
01.05.2018