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Document type:
Zeitschriftenaufsatz
Author(s):
Froehlich, John W.; Dodds, Eric D.; Wilhelm, Mathias; Serang, Oliver; Steen, Judith A.; Lee, Richard S.
Title:
A Classifier Based on Accurate Mass Measurements to Aid Large Scale, Unbiased Glycoproteomics
Abstract:
Determining which glycan moieties occupy specific N-glycosylation sites is a highly challenging analytical task. Arguably, the most common approach involves LC-MS and LC-MS/MS analysis of glycopeptides generated by proteases with high cleavage site specificity; however, the depth achieved by this approach is modest. Nonglycosylated peptides are a major challenge to glycoproteomics, as they are preferentially selected for data-dependent MS/MS due to higher ionization efficiencies and higher stoi...    »
Journal title:
Molecular & Cellular Proteomics
Year:
2013
Journal volume:
12
Journal issue:
4
Pages contribution:
1017-1025
Publisher:
Elsevier BV
E-ISSN:
1535-9476
Date of publication:
01.04.2013
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