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Document type:
Zeitschriftenaufsatz 
Author(s):
Reinecke, Maria; Ruprecht, Benjamin; Poser, Sandra; Wiechmann, Svenja; Wilhelm, Mathias; Heinzlmeir, Stephanie; Kuster, Bernhard; Médard, Guillaume 
Title:
Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors 
Abstract:
Chemical proteomic approaches utilizing immobilized, broad-selective kinase inhibitors (Kinobeads) have proven valuable for the elucidation of a compound’s target profile under close-to-physiological conditions and often revealed potentially synergistic or toxic off-targets. Current Kinobeads enrich more than 300 native protein kinases from cell line or tissue lysates but do not systematically cover phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related kinases (PIKKs)....    »
 
Journal title:
ACS Chemical Biology 
Year:
2019 
Journal volume:
14 
Journal issue:
Pages contribution:
655-664 
Publisher:
American Chemical Society (ACS) 
E-ISSN:
1554-89291554-8937 
Date of publication:
22.03.2019