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Titel:

Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Koch, Heiner; Wilhelm, Mathias; Ruprecht, Benjamin; Beck, Scarlet; Frejno, Martin; Klaeger, Susan; Kuster, Bernhard
Abstract:
Although substantial progress has been made regarding the use of molecularly targeted cancer therapies, resistance almost invariably develops and presents a major clinical challenge. The tumor microenvironment can rescue cancer cells from kinase inhibitors by growth-factor-mediated induction of pro-survival pathways. Here we show that epidermal growth factor receptor (EGFR) inhibition by Gefitinib is counteracted by growth factors, notably FGF2, and we assessed the global molecular consequences...     »
Zeitschriftentitel:
Journal of Proteome Research
Jahr:
2016
Band / Volume:
15
Heft / Issue:
12
Seitenangaben Beitrag:
4490-4504
Volltext / DOI:
doi:10.1021/acs.jproteome.6b00621
Verlag / Institution:
American Chemical Society (ACS)
E-ISSN:
1535-38931535-3907
Publikationsdatum:
16.11.2016
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