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Title:

NEDD8 - its role in the regulation of Cullin-RING ligases.

Document type:
Zeitschriftenaufsatz
Author(s):
Claus Schwechheimer
Abstract:
The ubiquitin-related protein NEDD8 is conjugated and deconjugated to and from proteins in processes related to ubiquitin conjugation and deconjugation. Neddylation is a well-studied posttranslational modification of Cullin-RING E3 ligases (CRLs). Biochemical and structural studies aiming at understanding the role of NEDD8 in CRL function have now resulted in a convincing model of how neddylation and deneddylation antagonistically regulate CRL stability, conformation, activity as well as degrada...     »
Keywords:
NEDD8, ubiquitin, protein, Cullin-RING E3, arabidopsis thaliana, auxin
Journal title:
Curr. Opin. Plant Biol.
Year:
2018
Year / month:
2018-10
Journal issue:
45
Pages contribution:
112-119
Language:
en
Fulltext / DOI:
doi:doi.org/10.1016/j.pbi.2018.05.017
WWW:
https://www.sciencedirect.com/science/article/pii/S1369526618300402
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