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Titel:

Capsaicin-sensitive extrinsic afferents are involved in acid-induced activation of distinct myenteric neurons in the rat stomach.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Schicho, R.; Schemann, M.; Pabst, M. A.; Holzer, P.; Lippe, I. T. H.
Abstract:
Challenge of the rat gastric mucosa with 0.5 mol L(-1) HCl activates nitrergic neurons in the myenteric plexus as visualized by c-Fos immunohistochemistry. In the present study, we characterized the activated neurons more extensively by their chemical coding and investigated whether a neural pathway that involves capsaicin-sensitive extrinsic afferents and/or cholinergic neurons transmitting via nicotinic receptors contributes to the activation of myenteric neurons. In multiple labelling experim...     »
Stichworte:
Cells, Cultured, Microscopy, Confocal, Immunohistochemistry, Animals, Female, Rats, Rats, Sprague-Dawley, Capsaicin/pharmacology, Ganglionic Blockers/pharmacology, Gastric Mucosa/*innervation/metabolism, Genes, fos/drug effects/*physiology, Hexamethonium/pharmacology, Hydrochloric Acid/pharmacology, Myenteric Plexus/cytology/drug effects/*physiology, Neural Pathways/cytology/drug effects, Neurons, Afferent/drug effects/*physiology
Zeitschriftentitel:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Jahr:
2003
Band / Volume:
15
Monat:
feb
Heft / Issue:
1
Seitenangaben Beitrag:
33--44
Sprache:
eng
Print-ISSN:
1350-1925 1350-1925
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