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Title:

Toxin {B} of {Clostridium} difficile activates human {VIP} submucosal neurons, in part via an {IL}-1beta-dependent pathway.

Document type:
Zeitschriftenaufsatz
Author(s):
Neunlist, M.; Barouk, J.; Michel, K.; Just, I.; Oreshkova, T.; Schemann, M.; Galmiche, J. P.
Abstract:
This study investigated whether toxin B of Clostridium difficile can activate human submucosal neurons and the involved pathways. Isolated segments of human colon were placed in organ culture for 3 h in the presence of toxin B or
Keywords:
Immunohistochemistry, Humans, In Vitro Techniques, Aged, Colon/*innervation, *Bacterial Proteins, Bacterial Toxins/*pharmacology, Interleukin-1/pharmacology/*physiology, Membrane Potentials/drug effects, Neurons/drug effects/metabolism/*physiology, Proto-Oncogene Proteins c-fos/metabolism, Submucous Plexus/cytology/drug effects/metabolism/*physiology, Vasoactive Intestinal Peptide/*metabolism
Journal title:
American journal of physiology. Gastrointestinal and liver physiology
Year:
2003
Journal volume:
285
Month:
nov
Journal issue:
5
Pages contribution:
G1049--1055
Language:
eng
Fulltext / DOI:
doi:10.1152/ajpgi.00487.2002
Print-ISSN:
0193-1857 0193-1857
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