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- Title:
Toxin {B} of {Clostridium} difficile activates human {VIP} submucosal neurons, in part via an {IL}-1beta-dependent pathway.
- Document type:
- Zeitschriftenaufsatz
- Author(s):
- Neunlist, M.; Barouk, J.; Michel, K.; Just, I.; Oreshkova, T.; Schemann, M.; Galmiche, J. P.
- Abstract:
- This study investigated whether toxin B of Clostridium difficile can activate human submucosal neurons and the involved pathways. Isolated segments of human colon were placed in organ culture for 3 h in the presence of toxin B or
- Keywords:
- Immunohistochemistry, Humans, In Vitro Techniques, Aged, Colon/*innervation, *Bacterial Proteins, Bacterial Toxins/*pharmacology, Interleukin-1/pharmacology/*physiology, Membrane Potentials/drug effects, Neurons/drug effects/metabolism/*physiology, Proto-Oncogene Proteins c-fos/metabolism, Submucous Plexus/cytology/drug effects/metabolism/*physiology, Vasoactive Intestinal Peptide/*metabolism
- Journal title:
- American journal of physiology. Gastrointestinal and liver physiology
- Year:
- 2003
- Journal volume:
- 285
- Month:
- nov
- Journal issue:
- 5
- Pages contribution:
- G1049--1055
- Language:
- eng
- Fulltext / DOI:
- doi:10.1152/ajpgi.00487.2002
- Print-ISSN:
- 0193-1857 0193-1857
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