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Titel:

Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery

Dokumenttyp:
Buchbeitrag
Autor(en):
Reinecke, Maria; Heinzlmeir, Stephanie; Wilhelm, Mathias; Médard, Guillaume; Klaeger, Susan; Kuster, Bernhard
Abstract:
Summary Protein kinases are key regulators of cellular signal transduction with crucial roles for healthy cell biology and pathogenesis. Accordingly many drugs have been developed to address the dysregulation of these enzymes, notably in oncology. Around 50 small molecule kinase inhibitors have already been approved, and hundreds of such drugs are the object of clinical investigation to combat these disease drivers with targeted therapeutic approaches. Due to the conserved structure of the kinas...     »
Seitenangaben Beitrag:
97-130
Kapitel Beitrag:
4
Stichworte:
kinase inhibitors, chemical proteomics, Kinobeads, selectivity, mass spectrometry, binding assay
Buchtitel:
Target Discovery and Validation
Verlag / Institution:
John Wiley & Sons, Ltd
Jahr:
2019
Print-ISBN:
9783527818242
DOI:
doi:https://doi.org/10.1002/9783527818242.ch4
WWW:
https://onlinelibrary.wiley.com/doi/abs/10.1002/9783527818242.ch4
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