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Titel:

A Classifier Based on Accurate Mass Measurements to Aid Large Scale, Unbiased Glycoproteomics

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Froehlich, John W.; Dodds, Eric D.; Wilhelm, Mathias; Serang, Oliver; Steen, Judith A.; Lee, Richard S.
Abstract:
Determining which glycan moieties occupy specific N-glycosylation sites is a highly challenging analytical task. Arguably, the most common approach involves LC-MS and LC-MS/MS analysis of glycopeptides generated by proteases with high cleavage site specificity; however, the depth achieved by this approach is modest. Nonglycosylated peptides are a major challenge to glycoproteomics, as they are preferentially selected for data-dependent MS/MS due to higher ionization efficiencies and higher stoi...     »
Zeitschriftentitel:
Molecular & Cellular Proteomics
Jahr:
2013
Band / Volume:
12
Heft / Issue:
4
Seitenangaben Beitrag:
1017-1025
Volltext / DOI:
doi:10.1074/mcp.m112.025494
Verlag / Institution:
Elsevier BV
E-ISSN:
1535-9476
Publikationsdatum:
01.04.2013
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