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Titel:

Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Reinecke, Maria; Ruprecht, Benjamin; Poser, Sandra; Wiechmann, Svenja; Wilhelm, Mathias; Heinzlmeir, Stephanie; Kuster, Bernhard; Médard, Guillaume
Abstract:
Chemical proteomic approaches utilizing immobilized, broad-selective kinase inhibitors (Kinobeads) have proven valuable for the elucidation of a compound’s target profile under close-to-physiological conditions and often revealed potentially synergistic or toxic off-targets. Current Kinobeads enrich more than 300 native protein kinases from cell line or tissue lysates but do not systematically cover phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related kinases (PIKKs)....     »
Zeitschriftentitel:
ACS Chemical Biology
Jahr:
2019
Band / Volume:
14
Heft / Issue:
4
Seitenangaben Beitrag:
655-664
Volltext / DOI:
doi:10.1021/acschembio.8b01020
Verlag / Institution:
American Chemical Society (ACS)
E-ISSN:
1554-89291554-8937
Publikationsdatum:
22.03.2019
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