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Title:

Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-{HT}3 receptors of enteric neurons.

Document type:
Zeitschriftenaufsatz
Author(s):
Walstab, J.; Kruger, D.; Stark, T.; Hofmann, T.; Demir, I. E.; Ceyhan, G. O.; Feistel, B.; Schemann, M.; Niesler, B.
Abstract:
BACKGROUND: Beneficial effects of ginger in the treatment of gastrointestinal (GI) problems and chemotherapy-induced nausea and vomiting are well accepted. In rodents, the action of ginger seems to be mediated by the inhibition of 5-HT3 receptors, which are established targets to combat emesis and irritable bowel syndrome. METHODS: Heterologously expressed human 5-HT3 A or 5-HT3 AB receptors were characterized by means of Ca(2+) influx studies using HEK293 cells. Complementing Ca(2+) measuremen...     »
Keywords:
Humans, HEK293 Cells, Plant Extracts/*pharmacology, Catechols/*pharmacology, Fatty Alcohols/*pharmacology, Ginger/chemistry, Neurons/*drug effects/metabolism, Receptors, Serotonin, 5-HT3/metabolism, Recombinant Proteins/metabolism, Serotonin 5-HT3 Receptor Antagonists/*pharmacology, Submucous Plexus/*drug effects/metabolism
Journal title:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Year:
2013
Journal volume:
25
Month:
may
Journal issue:
5
Pages contribution:
439--447, e302
Language:
eng
Fulltext / DOI:
doi:10.1111/nmo.12107
Print-ISSN:
1365-2982 1350-1925
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