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Titel:

bis-(p-hydroxyphenyl)-pyridyl-2-methane ({BHPM})-the active metabolite of the laxatives bisacodyl and sodium picosulfate-enhances contractility and secretion in human intestine in vitro.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Krueger, D.; Demir, I. E.; Ceyhan, G. O.; Zeller, F.; Schemann, M.
Abstract:
BACKGROUND: Stimulant laxatives are widely used to treat constipation. We investigated in human small and large intestinal preparations the effects of bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), the active metabolite of the laxatives bisacodyl and sodium picosulfate on smooth muscle tone and epithelial secretion. METHODS: Circular and longitudinal muscle tone of small or large intestinal preparations were recorded with isometric force transducers. Epithelial ion flux (ISC ) and tissue resist...     »
Stichworte:
bis-(p-hydroxyphenyl)-pyridyl-2-methane, laxative, motility, secretion
Zeitschriftentitel:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Jahr:
2018
Monat:
feb
Sprache:
eng
Volltext / DOI:
doi:10.1111/nmo.13311
Print-ISSN:
1365-2982 1350-1925
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