4D Printed Soft and Stretchable Self‐folding Cuff Electrodes for Small‐nerve Interfacing

Hiendlmeier, Lukas; Zurita, Francisco; Vogel, Jonas; Duca, Fulvia Del; Boustani, George Al; Peng, Hu; Kopic, Inola; Nikić, Marta; Teshima, Tetsuhiko; Wolfrum, Bernhard

doi:10.1002/adma.202210206

Neuroelektronik (Prof. Wolfrum)

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Title:: 4D Printed Soft and Stretchable Self‐folding Cuff Electrodes for Small‐nerve Interfacing
Document type:: Zeitschriftenaufsatz
Author(s):: Hiendlmeier, Lukas; Zurita, Francisco; Vogel, Jonas; Duca, Fulvia Del; Boustani, George Al; Peng, Hu; Kopic, Inola; Nikić, Marta; Teshima, Tetsuhiko; Wolfrum, Bernhard
Abstract:: Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the interfacing procedure, which limit their clinical application, in particular, when targeting small peripheral nerves (<200 µm). To improve the electrode handling and implantation, a nerve interface that can fold itself to a cuff around a small nerve, triggered by the body moisture during insertion, is fabricated. This folding is achieved by printing a bilayer of a flexible polyurethane printing resin and a highly swelling sodium acrylate hydrogel using photopolymerization. When immersed in an aqueous liquid, the hydrogel swells and folds the electrode softly around the nerve. Furthermore, the electrodes are robust, can be stretched (>20%), and bent to facilitate the implantation due to the use of soft and stretchable printing resins as substrates and a microcracked gold film as conductive layer. The straightforward implantation and extraction of the electrode as well as stimulation and recording capabilities on a small peripheral nerve in vivo are demonstrated. It is believed that such simple and robust to use self-folding electrodes will pave the way for bringing PNI to a broader clinical application.
Journal title:: Advanced Materials
Year:: 2023
Pages contribution:: 2210206
Fulltext / DOI:: doi:10.1002/adma.202210206
Publisher:: Wiley
E-ISSN:: 0935-96481521-4095
Date of publication:: 02.01.2023
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Computation, Information and Technology Departments Electrical Engineering Neuroelektronik (Prof. Wolfrum)Publikationen 2023

mediaTUM Gesamtbestand Hochschulbibliographie 2023 Schools und Fakultäten TUM School of Computation, Information and Technology Neuroelektronik (Prof. Wolfrum)