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Title:

Evaluation of the relevance of the glassy state as stability criterion for freeze-dried bacteria by application of the Arrhenius and WLF~model

Document type:
Zeitschriftenaufsatz
Author(s):
Aschenbrenner, M.; Kulozik, U.; Foerst, P.
Abstract:
The aim of this work was to describe the temperature dependence of microbial inactivation for several storage conditions and protective systems (lactose, trehalose and dextran) in relation to the physical state of the sample, i.e. the glassy or non-glassy state. The resulting inactivation rates k were described by applying two models, Arrhenius and Williams--Landel--Ferry (WLF), in order to evaluate the relevance of diffusional limitation as a protective mechanism. The application of the Arrheni...     »
Keywords:
Arrhenius; Bacteria; Freeze-drying; Glassy state; restriced diffusion; Storage stability; WLF
Journal title:
Cryobiology
Year:
2012
Journal volume:
65
Pages contribution:
308--318
Fulltext / DOI:
doi:10.1016/j.cryobiol.2012.08.005
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