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Title:

The Influence of Local Microstructure Inhomogeneities on Local Drying Kinetics during Freeze-Drying

Document type:
Zeitschriftenaufsatz
Author(s):
Gruber, Sebastian; Thomik, Maximilian; Vorhauer-Huget, Nicole; Hans, Lukas; Tsotsas, Evangelos; Foerst, Petra
Abstract:
Freeze-drying is a gentle drying technique to dry high value products, such as pharmaceuticals, without impacting the quality of the product. However, this method is very time and cost intensive. It is known that larger pores reduce the duration of primary drying due to facilitated mass transport. However, next to the pore size, other structural parameters exist whose influence on drying kinetics is still unknown. Therefore, the aim of this article is to investigate the influence of the microstr...     »
Keywords:
drying kinetics; Freeze-drying; image analysis; lyomicroscope; Maltodextrin; microstructure; sucrose
Journal title:
Pharmaceutics
Year:
2022
Journal volume:
14
Journal issue:
10
Fulltext / DOI:
doi:10.3390/pharmaceutics14102132
Print-ISSN:
1999-4923
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