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Title:

Development of a hydrophilic liquid interaction chromatography-high-performance liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis and pharmacokinetic studies on bioactive pyridines in human plasma and urine after coffee consumption

Document type:
Zeitschriftenaufsatz
Author(s):
Lang, Roman; Wahl, Anika; Skurk, Thomas; Yagar, Erkan Firat; Schmiech, Ludger; Eggers, Rudolf; Hauner, Hans; Hofmann, Thomas
Abstract:
The paper reports on the development of an accurate hydrophilic liquid interaction chromatography tandem mass spectrometry (HILIC-MS/MS) based stable isotope dilution analysis for the simultaneous quantitation of the food-derived bioactive pyridines trigonelline, nicotinic acid, nicotinamide, and N-methylpyridinium, as well as their key metabolites nicotinamide-N-oxide, N-methylnicotinamide, N-methyl-2-pyridone-5-carboxamide, N-methyl-4-pyridone-5-carboxamide, and N-methyl-2-pyridone-5-carboxyli...     »
Journal title:
Analytical Chemistry
Year:
2010
Journal volume:
82
Journal issue:
4
Pages contribution:
1486--1497
Fulltext / DOI:
doi:10.1021/ac902616k
Print-ISSN:
0003-2700
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