Cerulein-induced chronic pancreatitis (CP) was exacerbated in TRPV6mut/mut mice.
Erläuterung:
Cerulein-induced chronic pancreatitis (CP) was exacerbated in TRPV6mut/mut mice.
(A) TRPV6mut/mut and control mice (129B6F1) were injected intraperitoneally each hour for 8h per day during two consecutive days (d1, d2) with 0.1 mg cerulein/ g mouse body weight. Blood was taken at 0 h, 8 h, 24 h, 32 h, and at sacrifice 96 h (d5)
after the first injection. (B) Quantification of serum amylase and lipase (U/l) at 0 h, 8 h,
24 h, 32 h, and 96 h after the first cerulein injection; mean+SEM (n=5), ***P<0.001, **P<0.01, *P<0.05. (C) H&E (morphology) and Sirius Red (fibrosis) staining of TRPV6mut/mut and control tissue sections at sacrifice compared to control mice; scale bar = 100 mm. Lower panels represent enlarged images.
Ereignis / Anlass:
Pressemitteilung Krankheitsauslöser für Pankreatitis identifiziert
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