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Title:

Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation

Document type:
Zeitschriftenaufsatz
Author(s):
Niu, Yunhui; Heddes, Marjolein; Altaha, Baraa; Birkner, Michael; Kleigrewe, Karin; Meng, Chen; Haller, Dirk; Kiessling, Silke
Abstract:
The expression of clock genes has been observed to be impaired in biopsies from patients with inflammatory bowel disease (IBD). Disruption of circadian rhythms, which occurs in shift workers, has been linked to an increased risk of gastrointestinal diseases, including IBD. The peripheral circadian clock in intestinal epithelial cells (IECs) was previously shown to balance gastrointestinal homeostasis by regulating the microbiome. Here, we demonstrated that the intestinal clock is disrupted in an...     »
Keywords:
BayBioMS; Gastrointestinal inflammation; IBD; Intestinal circadian clock; Microbiota; Restricted feeding.
Journal title:
Cellular & Molecular Immunology
Year:
2024
Fulltext / DOI:
doi:10.1038/s41423-024-01189-z
Publisher:
Springer Science and Business Media LLC
E-ISSN:
2042-0226
Date of publication:
25.06.2024
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