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Title:

Neocarzilin Inhibits Cancer Cell Proliferation via BST-2 Degradation, Resulting in Lipid Raft-Trapped EGFR

Document type:
Zeitschriftenaufsatz
Author(s):
Braun, Josef; Hu, Yudong; Jauch, Adrian T.; Gronauer, Thomas F.; Mergner, Julia; Bach, Nina C.; Traube, Franziska R.; Zahler, Stefan; Sieber, Stephan A.
Abstract:
Neocarzilin (NCA) is a natural product exhibiting potent antimigratory as well as antiproliferative effects. While vesicle amine transport protein 1 (VAT-1) was previously shown to inhibit migration upon NCA binding, the molecular mechanisms responsible for impaired proliferation remained elusive. We here introduce a chemical probe closely resembling the structural and stereochemical features of NCA and unravel bone marrow stromal antigen 2 (BST-2) as one of the targets responsible for the antip...     »
Keywords:
BayBioMS@MRI
Journal title:
JACS Au
Year:
2024
Journal volume:
4
Journal issue:
5
Pages contribution:
1833-1840
Fulltext / DOI:
doi:10.1021/jacsau.4c00039
Publisher:
American Chemical Society (ACS)
E-ISSN:
2691-37042691-3704
Date of publication:
08.05.2024
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