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Titel:

Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Stepan, Jens; Heinz, Daniel E.; Dethloff, Frederik; Wiechmann, Svenja; Martinelli, Silvia; Hafner, Kathrin; Ebert, Tim; Junglas, Ellen; Häusl, Alexander S.; Pöhlmann, Max L.; Jakovcevski, Mira; Pape, Julius C.; Zannas, Anthony S.; Bajaj, Thomas; Hermann, Anke; Ma, Xiao; Pavenstädt, Hermann; Schmidt, Mathias V.; Philipsen, Alexandra; Turck, Christoph W.; Deussing, Jan M.; Rammes, Gerhard; Robinson, Andrew C.; Payton, Antony; Wehr, Michael C.; Stein, Valentin; Murgatroyd, Christopher; Kremerskothe...     »
Abstract:
The localization, number, and function of postsynaptic AMPA-type glutamate receptors (AMPARs) are crucial for synaptic plasticity, a cellular correlate for learning and memory. The Hippo pathway member WWC1 is an important component of AMPAR-containing protein complexes. However, the availability of WWC1 is constrained by its interaction with the Hippo pathway kinases LATS1 and LATS2 (LATS1/2). Here, we explored the biochemical regulation of this interaction and found that it is pharmacologicall...     »
Stichworte:
BayBioMS; Alzheimer Disease / metabolism Animals Hepatocyte Growth Factor / metabolism Hippo Signaling Pathway Hippocampus* / metabolism Humans Intracellular Signaling Peptides and Proteins* Male Memory / physiology Mice Mice, Inbred C57BL Neuronal Plasticity* / physiology Neurons / metabolism Phosphoproteins* Phosphorylation Protein Serine-Threonine Kinases* / genetics Protein Serine-Threonine Kinases* / metabolism Receptors, AMPA* / genetics Receptors, AMPA* / metabolism Serine-Threonine Kina...     »
Zeitschriftentitel:
Science Signaling
Jahr:
2024
Band / Volume:
17
Heft / Issue:
834
Volltext / DOI:
doi:10.1126/scisignal.adj6603
Verlag / Institution:
American Association for the Advancement of Science (AAAS)
E-ISSN:
1945-08771937-9145
Publikationsdatum:
30.04.2024
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