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Title:

Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression

Document type:
Zeitschriftenaufsatz
Author(s):
Ecker, Veronika; Brandmeier, Lisa; Stumpf, Martina; Giansanti, Piero; Moreira, Aida Varela; Pfeuffer, Lisa; Fens, Marcel H.A.M.; Lu, Junyan; Kuster, Bernhard; Engleitner, Thomas; Heidegger, Simon; Rad, Roland; Ringshausen, Ingo; Zenz, Thorsten; Wendtner, Clemens-Martin; Müschen, Markus; Jellusova, Julia; Ruland, Jürgen; Buchner, Maike
Abstract:
Despite available targeted treatments for the disease, drug-resistant chronic lymphocytic leukemia (CLL) poses a clinical challenge. The objective of this study is to examine whether the dual-specific phosphatases DUSP1 and DUSP6 are required to negatively regulate mitogen-activated protein kinases (MAPKs) and thus counterbalance excessive MAPK activity. We show that high expression of DUSP6 in CLL correlates with poor clinical prognosis. Importantly, genetic deletion of the inhibitory phosphata...     »
Keywords:
BayBioMS@MRI, CLL; CP: Cancer; DNA damage; MAPK; apoptosis; phosphatases
Journal title:
Cell Reports
Year:
2023
Journal volume:
42
Journal issue:
10
Pages contribution:
113017
Fulltext / DOI:
doi:10.1016/j.celrep.2023.113017
Publisher:
Elsevier BV
E-ISSN:
2211-1247
Date of publication:
01.10.2023
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