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Titel:

Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Ecker, Veronika; Brandmeier, Lisa; Stumpf, Martina; Giansanti, Piero; Moreira, Aida Varela; Pfeuffer, Lisa; Fens, Marcel H.A.M.; Lu, Junyan; Kuster, Bernhard; Engleitner, Thomas; Heidegger, Simon; Rad, Roland; Ringshausen, Ingo; Zenz, Thorsten; Wendtner, Clemens-Martin; Müschen, Markus; Jellusova, Julia; Ruland, Jürgen; Buchner, Maike
Abstract:
Despite available targeted treatments for the disease, drug-resistant chronic lymphocytic leukemia (CLL) poses a clinical challenge. The objective of this study is to examine whether the dual-specific phosphatases DUSP1 and DUSP6 are required to negatively regulate mitogen-activated protein kinases (MAPKs) and thus counterbalance excessive MAPK activity. We show that high expression of DUSP6 in CLL correlates with poor clinical prognosis. Importantly, genetic deletion of the inhibitory phosphata...     »
Stichworte:
BayBioMS@MRI, CLL; CP: Cancer; DNA damage; MAPK; apoptosis; phosphatases
Zeitschriftentitel:
Cell Reports
Jahr:
2023
Band / Volume:
42
Heft / Issue:
10
Seitenangaben Beitrag:
113017
Volltext / DOI:
doi:10.1016/j.celrep.2023.113017
Verlag / Institution:
Elsevier BV
E-ISSN:
2211-1247
Publikationsdatum:
01.10.2023
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