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Title:

Synthetic Mucin Gels with Self‐Healing Properties Augment Lubricity and Inhibit HIV‐1 and HSV‐2 Transmission

Document type:
Zeitschriftenaufsatz
Author(s):
Kretschmer, Martin; Ceña‐Diez, Rafael; Butnarasu, Cosmin; Silveira, Valentin; Dobryden, Illia; Visentin, Sonja; Berglund, Per; Sönnerborg, Anders; Lieleg, Oliver; Crouzier, Thomas; Yan, Hongji
Abstract:
Mucus is a self-healing gel that lubricates the moist epithelium and provides protection against viruses by binding to viruses smaller than the gel's mesh size and removing them from the mucosal surface by active mucus turnover. As the primary nonaqueous components of mucus (≈0.2%–5%, wt/v), mucins are critical to this function because the dense arrangement of mucin glycans allows multivalence of binding. Following nature's example, bovine submaxillary mucins (BSMs) are assembled into “mucus-lik...     »
Keywords:
HIV-1; HSV-2; immune suppression; lubricant; mucin hydrogels; self-healing; strain-weakening
Dewey Decimal Classification:
500 Naturwissenschaften
Journal title:
Advanced Science
Year:
2022
Journal volume:
9
Journal issue:
32
Pages contribution:
2203898
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1002/advs.202203898
WWW:
https://onlinelibrary.wiley.com/doi/10.1002/advs.202203898
Publisher:
Wiley
E-ISSN:
2198-38442198-3844
Date of publication:
14.09.2022
TUM Institution:
Fachgebiet für Biomechanik, MW
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