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Titel:

Tailored mechanosensitive nanogels release drugs upon exposure to different levels of stenosis

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Kimna, Ceren; Miller Naranjo, Bernardo; Eckert, Franziska; Fan, Di; Arcuti, Dario; Mela, Petra; Lieleg, Oliver
Abstract:
Owing to the unhealthy lifestyle and genetic susceptibility of today's population, atherosclerosis is one of the global leading causes of life-threatening cardiovascular diseases. Although a rapid intervention is required for severe blood vessel constrictions, a systemic administration of anticoagulant drugs is not the preferred method of choice as the associated risk of bleeding complications is high. In this study, we present mechanosensitive nanogels that exhibit tunable degrees of disintegra...     »
Stichworte:
mechanosensitive nanogels; charged drug molecules; drug delivery
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
Nanoscale
Jahr:
2022
Band / Volume:
14
Heft / Issue:
46
Seitenangaben Beitrag:
17196-17209
Nachgewiesen in:
Scopus
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1039/d2nr03292a
WWW:
https://pubs.rsc.org/en/content/articlelanding/2022/nr/d2nr03292a#!divAbstract
Verlag / Institution:
Royal Society of Chemistry (RSC)
E-ISSN:
2040-33642040-3372
Publikationsdatum:
01.01.2022
TUM Einrichtung:
Fachgebiet für Biomechanik, MW
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