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Document type:
Zeitschriftenaufsatz 
Author(s):
Klooker, Tamira K.; Braak, Breg; Koopman, Karin E.; Welting, Olaf; Wouters, Mira M.; van der Heide, Sicco; Schemann, Michael; Bischoff, Stephan C.; van den Wijngaard, Rene M.; Boeckxstaens, Guy E. 
Title:
The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. 
Abstract:
BACKGROUND: Mast cell activation is thought to be involved in visceral hypersensitivity, one of the main characteristics of the irritable bowel syndrome (IBS). A study was therefore undertaken to investigate the effect of the mast cell stabiliser ketotifen on rectal sensitivity and symptoms in patients with IBS. METHODS: 60 patients with IBS underwent a barostat study to assess rectal sensitivity before and after 8 weeks of treatment. After the initial barostat, patients were randomised to recei...    »
 
Keywords:
Pressure, Treatment Outcome, Cell Count, Humans, Adult, Aged, Female, Male, Middle Aged, Histamine Release/drug effects, Young Adult, Double-Blind Method, Elasticity/drug effects, Histamine H1 Antagonists/adverse effects/*therapeutic use, Irritable Bowel Syndrome/*drug therapy/pathology/physiopathology, Ketotifen/adverse effects/*therapeutic use, Mast Cells/pathology, Quality of Life, Rectum/metabolism/physiopathology, Sensory Thresholds/drug effects/physiology, Tryptases/metabolism, Viscera/dru...    »
 
Journal title:
Gut 
Year:
2010 
Journal volume:
59 
Month:
sep 
Journal issue:
Pages contribution:
1213--1221 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1468-3288 0017-5749