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Document type:
Zeitschriftenaufsatz 
Author(s):
Breuer, Christian; Oh, Jun; Molderings, Gerhard-J.; Schemann, Michael; Kuch, Birgit; Mayatepek, Ertan; Adam, Rudiger 
Title:
Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations. 
Abstract:
Constipation and fecal impaction are frequent and distressing complaints in pediatric gastroenterology. Especially in neurologically handicapped children, treatment of severe forms of slow-transit constipation (STC) can be difficult. In the majority of cases, STC is of unknown etiology. However, in recent years, there is growing evidence that interstitial cells of Cajal (ICCs), which serve as electrical pacemakers and generate spontaneous electrical slow waves in the gastrointestinal tract, migh...    »
 
Keywords:
Humans, Adolescent, Male, *Gastrointestinal Transit, *Mutation, Constipation/*etiology, Interstitial Cells of Cajal/*pathology, Proto-Oncogene Proteins c-kit/*genetics 
Journal title:
World journal of gastroenterology 
Year:
2010 
Journal volume:
16 
Month:
sep 
Journal issue:
34 
Pages contribution:
4363--4366 
Language:
eng 
Print-ISSN:
2219-2840 1007-9327