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Titel:

Anti-{Hu} antibodies activate enteric and sensory neurons.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Li, Qin; Michel, Klaus; Annahazi, Anita; Demir, Ihsan E.; Ceyhan, Guralp O.; Zeller, Florian; Komorowski, Lars; Stocker, Winfried; Beyak, Michael J.; Grundy, David; Farrugia, Gianrico; De Giorgio, Roberto; Schemann, Michael
Abstract:
IgG of type 1 anti-neuronal nuclear antibody (ANNA-1, anti-Hu) specificity is a serological marker of paraneoplastic neurological autoimmunity (including enteric/autonomic) usually related to small-cell lung carcinoma. We show here that IgG isolated from such sera and also affinity-purified anti-HuD label enteric neurons and cause an immediate spike discharge in enteric and visceral sensory neurons. Both labelling and activation of enteric neurons was prevented by preincubation with the HuD anti...     »
Zeitschriftentitel:
Scientific reports
Jahr:
2016
Band / Volume:
6
Monat:
dec
Seitenangaben Beitrag:
38216
Sprache:
eng
Volltext / DOI:
doi:10.1038/srep38216
Print-ISSN:
2045-2322 2045-2322
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