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Titel:

Human native kappa opioid receptor functions not predicted by recombinant receptors: {Implications} for drug design.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Broad, John; Maurel, Damien; Kung, Victor W. S.; Hicks, Gareth A.; Schemann, Michael; Barnes, Michael R.; Kenakin, Terrence P.; Granier, Sebastien; Sanger, Gareth J.
Abstract:
If activation of recombinant G protein-coupled receptors in host cells (by drugs or other ligands) has predictive value, similar data must be obtained with native receptors naturally expressed in tissues. Using mouse and human recombinant kappa opioid receptors transfected into a host cell, two selectively-acting compounds (ICI204448, asimadoline) equi-effectively activated both receptors, assessed by measuring two different cell signalling pathways which were equally affected without evidence...     »
Zeitschriftentitel:
Scientific reports
Jahr:
2016
Band / Volume:
6
Monat:
aug
Seitenangaben Beitrag:
30797
Sprache:
eng
Volltext / DOI:
doi:10.1038/srep30797
Print-ISSN:
2045-2322 2045-2322
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