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Titel:

Hepatitis B virus targets lipid transport pathways to infect hepatocytes

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Esser, Knud; Cheng, Xiaoming; Wettengel, Jochen M.; Lucifora, Julie; Hansen-Palmus, Lea; Austen, Katharina; Suarez, Armando A.R.; Heintz, Sarah; Testoni, Barbara; Nebioglu, Firat; Pham, Minh Tu; Yang, Shangqing; Zernecke, Alma; Wohlleber, Dirk; Ringelhan, Marc; Broxtermann, Mathias; Hartmann, Daniel; Hüser, Norbert; Mergner, Julia; Pichlmair, Andreas; Thasler, Wolfgang E.; Heikenwalder, Mathias; Gasteiger, Georg; Blutke, Andreas; Walch, Axel; Knolle, Percy A.; Bartenschlager, Ralf; Protzer, Ulri...     »
Abstract:
Background and aims: A single hepatitis B virus (HBV) particle is sufficient to establish chronic infection of the liver after intravenous injection, suggesting that the virus targets hepatocytes via a highly efficient transport pathway. We therefore investigated whether HBV utilizes a physiological liver-directed pathway that supports specific host-cell targeting in vivo. Methods: We established an ex vivo system of perfused human liver tissue that recapitulates the liver physiology to inves...     »
Stichworte:
BayBioMS; Transcytosis; lipoprotein metabolism; liver targeting; trans-infection
Zeitschriftentitel:
Cellular and Molecular Gastroenterology and Hepatology
Jahr:
2023
Volltext / DOI:
doi:10.1016/j.jcmgh.2023.03.011
Verlag / Institution:
Elsevier BV
E-ISSN:
2352-345X
Publikationsdatum:
01.04.2023
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